The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

While conventional in vitro culture systems and animal models have been used to study the
pathogenesis of viral infections and to facilitate development of vaccines and therapeutics …

Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells
to form intracellular bacterial communities (IBCs) during early stages of urinary tract …

The inhalation toxicology of multifaceted particulate matter from the environment, cigarette
smoke, and e-cigarette liquid vapes is a major research topic concerning the adverse effect …

Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …

Severe cases of SARS‐CoV‐2 infection are characterized by hypercoagulopathies and
systemic endotheliitis of the lung microvasculature. The dynamics of vascular damage, and …

Research on microbial pathogens has traditionally relied on animal and cell culture models
to mimic infection processes in the host. Over recent years, developments in microfluidics …