1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Cellular membranes are composed of numerous kinds of glycerophospholipids with different
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Over one hundred different phospholipid molecular species are known to be present in
mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and
membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various …

Macrophages can be activated through TLRs for a variety of innate immune responses. In
contrast with the wealth of data existing on TLR-dependent gene expression and resultant …

We investigated the role of phospholipase A2 (PLA2) and the effects of PLA2 products
(polyunsaturated fatty acids and lysophospholipids) on the cold-sensitive channel transient …

This chapter explores the evidence supporting inflammation-associated depression. Data to
date suggest a bidirectional relationship between inflammation and depression wherein one …