Current physiologically based pharmacokinetic (PBPK) models are inductive. We present an
additional, different approach that is based on the synthetic rather than the inductive …

Purpose Validate a physiologically based, mechanistic, in silico liver (ISL) for studying the
hepatic disposition and metabolism of antipyrine, atenolol, labetalol, diltiazem, and sucrose …

Previous studies suggest that collaboration between management agencies and the public
has the potential to increase public approval of marine protected areas (MPAs). A social …

As they involve relationships between interacting individuals and groups, social systems can
be described at different levels of resolution. In a number of modeling cases, only one of …

Purpose The aims of this study were 1) to demonstrate a new modeling strategy that uses
experimental computational models built by the synthetic method and 2) to study the …

We report the development and use of a synthetic, discrete event, discrete space model that
functions as an epithelio-mimetic device (EMD). It is intended to facilitate the study of …

We propose to consider a multi-level representation from a multi-modeling point of view. We
define a framework to better specify the concepts used in multi-level modeling and their …

Purpose Validate and exemplify a discrete, componentized, in silico, transwell device (ISTD)
capable of mimicking the in vitro passive transport properties of compounds through cell …

We present a method for estimating (predicting) parameter values for an agent-based model
of in silico hepatocytes (ISH). The method enables the ISH to interact with simulated drugs to …

We present the basics of a modeling method, FURM (Functional Unit Representation
Method) that attempts to address a fundamental difference in the practice of biological …