Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …

The metastasis of cancer cells is the main cause of death in patients with gastric cancer
(GC). Mounting evidence has demonstrated the vital importance of tumor-associated …

Background Allergoid–mannan conjugates are novel vaccines for allergen-specific
immunotherapy being currently assayed in phase 2 clinical trials. Allergoid–mannan …

Gene editing of living cells has become a crucial tool in medical research, enabling
scientists to address fundamental biological questions and develop novel strategies for …

Background: High-mobility group box 1 protein (HMGB1) was identified as a highly
conserved DNA binding nuclear protein, which participates in the processes of acute lung …

Dendritic cells (DCs) undergo rapid metabolic reprogramming to generate signal-specific
immune responses. The fine control of cellular metabolism underlying DC immune tolerance …

Mycobacterium tuberculosis (Mtb) defends host-mediated killing by repressing the
autophagolysosome machinery. For the first time, we report NCoR1 co-repressor as a …

Immune checkpoint blockade (ICB) therapy has significantly progressed the treatment of
bladder cancer (BLCA). Multiple studies have suggested that specific genetic mutations may …

Dendritic cell (DC) fine-tunes inflammatory versus tolerogenic responses to protect from
immune-pathology. However, the role of co-regulators in maintaining this balance is …

Recently, cyclin-dependent kinase (CDK) 4/6 inhibitors have been widely used to treat
advanced hormone receptor-positive breast cancer. Despite promising clinical outcomes …