Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Aptamers chemistry: Chemical modifications and conjugation strategies

F Odeh, H Nsairat, W Alshaer, MA Ismail, E Esawi… - Molecules, 2019 - mdpi.com
Soon after they were first described in 1990, aptamers were largely recognized as a new
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …

Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology

N Bertrand, J Wu, X Xu, N Kamaly… - Advanced drug delivery …, 2014 - Elsevier
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …

Aptamer-functionalized nanoparticles in targeted delivery and cancer therapy

Z Fu, J Xiang - International Journal of Molecular Sciences, 2020 - mdpi.com
Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

J Nicolas, S Mura, D Brambilla, N Mackiewicz… - Chemical Society …, 2013 - pubs.rsc.org
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …

Multifunctional Fe3O4@Polydopamine Core–Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy

LS Lin, ZX Cong, JB Cao, KM Ke, QL Peng, J Gao… - ACS …, 2014 - ACS Publications
Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and
therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4 …

Developing mRNA-vaccine technologies

T Schlake, A Thess, M Fotin-Mleczek, KJ Kallen - RNA biology, 2012 - Taylor & Francis
mRNA vaccines combine desirable immunological properties with an outstanding safety
profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression …

Synthesis, functionalization, and design of magnetic nanoparticles for theranostic applications

J Mosayebi, M Kiyasatfar… - Advanced Healthcare …, 2017 - Wiley Online Library
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs)
have been presented as a class of non‐invasive nanomaterials for numerous biomedical …

Cancer‐targeting nanoparticles for combinatorial nucleic acid delivery

HJ Vaughan, JJ Green, SY Tzeng - Advanced Materials, 2020 - Wiley Online Library
Nucleic acids are a promising type of therapeutic for the treatment of a wide range of
conditions, including cancer, but they also pose many delivery challenges. For efficient and …