Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021 - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Silkworm silk-based materials and devices generated using bio-nanotechnology

W Huang, S Ling, C Li, FG Omenetto… - Chemical Society …, 2018 - pubs.rsc.org
Silks are natural fibrous protein polymers that are spun by silkworms and spiders. Among
silk variants, there has been increasing interest devoted to the silkworm silk of B. mori, due …

Structures, mechanical properties and applications of silk fibroin materials

LD Koh, Y Cheng, CP Teng, YW Khin, XJ Loh… - Progress in Polymer …, 2015 - Elsevier
For centuries, Bombyx mori silkworm silk fibroin has been used as a high-end textile fiber.
Beyond textiles, silk fibroin has also been used as a surgical suture material for decades …

Strategies to develop polymeric microneedles for controlled drug release

BZ Chen, YT He, ZQ Zhao, YH Feng, L Liang… - Advanced Drug Delivery …, 2023 - Elsevier
The remarkable appeal of microneedle controlled-release systems has captivated both the
academic community and pharmaceutical industry due to their great potential for achieving …

Microneedles: a new frontier in nanomedicine delivery

E Larrañeta, MTC McCrudden, AJ Courtenay… - Pharmaceutical …, 2016 - Springer
This review aims to concisely chart the development of two individual research fields,
namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles …

Fabrication, evaluation and applications of dissolving microneedles

L Zhang, R Guo, S Wang, X Yang, G Ling… - International journal of …, 2021 - Elsevier
In recent years, transdermal preparations have emerged as one of the most promising
modes of administration. In particular, dissolving microneedles have attracted extensive …

[HTML][HTML] Trends in drug-and vaccine-based dissolvable microneedle materials and methods of fabrication

LE Moore, S Vucen, AC Moore - European Journal of Pharmaceutics and …, 2022 - Elsevier
Microneedle patches, also called microarray patches (MAP), are an emerging technology for
delivery and sampling of drugs, vaccines and other materials. This review focuses on the …

Dissolving microneedles for transdermal drug delivery: Advances and challenges

K Ita - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Over the last number of years, a significant body of evidence has shown the benefit of using
dissolving microneedles (DMNs) for transdermal drug delivery. These devices are prepared …

Polymeric microneedles for controlled transdermal drug delivery

P Singh, A Carrier, Y Chen, S Lin, J Wang, S Cui… - Journal of controlled …, 2019 - Elsevier
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems
because of their controlled drug delivery, tunable properties, and ease of patient self …

A gelatin-sulfonated silk composite scaffold based on 3D printing technology enhances skin regeneration by stimulating epidermal growth and dermal …

S Xiong, X Zhang, P Lu, Y Wu, Q Wang, H Sun… - Scientific reports, 2017 - nature.com
One of the key problems hindering skin repair is the deficiency of dermal vascularization and
difficulty of epidermis regeneration, which makes it challenging to fabricate scaffolds that can …