A model and multi-core parallel co-evolution algorithm for identifying cancer driver pathways

X Chen, J Wu, Z Deng, G Li - Engineering Applications of Artificial …, 2024 - Elsevier
The identification of cancer driver pathways has become a significant issue in the field of
bioinformatics in recent years, for driver pathways are crucial for understanding the …

A nonlinear model and an algorithm for identifying cancer driver pathways

J Wu, X Chen, G Li, Z Deng, K Zhu - Applied Soft Computing, 2022 - Elsevier
The identification of driver pathways has attracted considerable attention in recent years due
to the high significance of driver pathways in cancer related studies. In most identification …

[HTML][HTML] IDM-SPS: Identifying driver module with somatic mutation, ppi network and subcellular localization

J Wu, J Yang, G Li, J Wang - Engineering Applications of Artificial …, 2021 - Elsevier
Mutation profiles together with prior knowledge such as interactions between genes/proteins
provide abundant critical information for the identification of driver modules, which is very …

A model and cooperative co-evolution algorithm for identifying driver pathways based on the integrated data and PPI network

K Zhu, J Wu, G Li, X Chen, MY Luo - Expert Systems with Applications, 2023 - Elsevier
Driver pathways have been acknowledged to play critical roles in the initiation and
progression of cancers► hence it is essential for precision medicine related studies to …

A model and algorithm for identifying driver pathways based on weighted non-binary mutation matrix

J Wu, K Zhu, G Li, J Wang, Q Cai - Applied Intelligence, 2022 - Springer
It is generally acknowledged that driver pathway plays a decisive role in the occurrence and
progress of tumors, and the identification of driver pathways has become imperative for …

Identifying driver modules based on multi‐omics biological networks in prostate cancer

Z Chen, B Liang, Y Wu, H Zhou, Y Wang… - IET Systems …, 2022 - Wiley Online Library
The development of sequencing technology has promoted the expansion of cancer genome
data. It is necessary to identify the pathogenesis of cancer at the molecular level and explore …

Identifying common driver modules by equilibrating coverage and mutual exclusivity across pan-cancer data

J Wu, C Wu, G Li - Neurocomputing, 2022 - Elsevier
It is of significance to identify common driver modules from pan-cancer data to interpret
heterogeneity of cancer, and the accumulated omic data have made it into reality. In this …

Identifying driver pathways based on a parameter-free model and a partheno-genetic algorithm

J Wu, Q Nie, G Li, K Zhu - BMC bioinformatics, 2023 - Springer
Background Tremendous amounts of omics data accumulated have made it possible to
identify cancer driver pathways through computational methods, which is believed to be able …

Biological Pathway Identification

Q Chen - Association Analysis Techniques and Applications in …, 2024 - Springer
Genome-wide association study (GWAS) has become an essential method to reveal the
genetic mechanism of complex diseases. In the past decade, the research on GWAS …

Computational approaches for the discovery of significant genes in cancer

JF Cutigi - 2021 - teses.usp.br
Cancer is a complex disease caused by the accumulation of genetic alterations during the
individuals life. These alterations are named genetic mutations, which may be divided into …