The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets
R Krishnakumar, WL Kraus - Molecular cell, 2010 - cell.com
The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …
Metabolic checkpoints in activated T cells
R Wang, DR Green - Nature immunology, 2012 - nature.com
The immunological process of clonal selection requires a rapid burst in lymphocyte
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …
proliferation, and this involves a metabolic shift to provide energy and the building blocks of …
DNA damage response and immune defense
C Nastasi, L Mannarino, M D'Incalci - International journal of molecular …, 2020 - mdpi.com
DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …
Nuclear ADP-ribosylation and its role in chromatin plasticity, cell differentiation, and epigenetics
MO Hottiger - Annual review of biochemistry, 2015 - annualreviews.org
Protein ADP-ribosylation is an ancient posttranslational modification with high biochemical
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …
complexity. It alters the function of modified proteins or provides a scaffold for the recruitment …
Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances
G Musso, F Saba, M Cassader, R Gambino - Progress in Lipid Research, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …
general adult population. NAFLD encompasses a histological spectrum ranging from pure …
[HTML][HTML] CD38: An important regulator of T cell function
W Li, L Liang, Q Liao, Y Li, Y Zhou - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Cluster of differentiation 38 (CD38) is a multifunctional extracellular enzyme on the
cell surface with NADase and cyclase activities. CD38 is not only expressed in human …
cell surface with NADase and cyclase activities. CD38 is not only expressed in human …
Beyond DNA repair, the immunological role of PARP‐1 and its siblings
MM Rosado, E Bennici, F Novelli, C Pioli - Immunology, 2013 - Wiley Online Library
ADP‐ribosylation is the addition of one or more (up to some hundreds) ADP‐ribose moieties
to acceptor proteins. There are two major families of enzymes that catalyse this reaction …
to acceptor proteins. There are two major families of enzymes that catalyse this reaction …