Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

Depression is a multicausal disorder and has been associated with the risk to develop
cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has …

This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

This introductory article to the special edition on glutamate neurotransmission in
neuropsychiatric disorders provides an overview of glutamate neurotransmitter system …

l‐Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …

Astrocytes, the most abundant glial cell types in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. Accordingly, impairment in these …

Pfaff presents a daring perspective on the long-standing puzzle of what arousal is. He
argues that, beneath our mental functions and emotional dispositions, a primitive neuronal …

Individuals addicted to drugs of abuse such as alcohol, nicotine, cocaine, and heroin are a
significant burden on healthcare systems all over the world. The positive reinforcing …

Major depression is a common, recurrent mental illness that affects millions of people
worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has …