The combination of computational design and directed evolution could offer a general
strategy to create enzymes with new functions. So far, this approach has delivered enzymes …

Since its discovery in the late 1960s, the Morita–Baylis–Hillman (MBH) reaction has
remained a powerful carbon–carbon σ-bond-forming transformation, producing small …

A protein's pool of functionalities presents a formidable challenge for its single-site
modification. Here, we report a method to harness protein–protein interaction (PPI) to drive …

Abstract The Morita‐Baylis‐Hillman (MBH) reaction affords highly functionalised allylic
alcohols containing a new stereogenic centre. These MBH adducts are very versatile and …

Indolizines and their saturated derivatives are important structural motifs present in several
biologically active compounds of both natural and synthetic origin. We describe herein a one …

Exploring the promiscuity of native enzymes presents a promising strategy for expanding
their synthetic applications, particularly for catalyzing challenging reactions in non-native …

We report a chemoselective and site-selective formylation of ε-amine in native proteins. The
aldehyde auto-oxidation re-routing, regulated generation of formate, and reversible N …

A series of deep eutectic solvents (DESs) based on choline chloride were prepared and
used in the Morita–Baylis–Hillman (M–B–H) reaction. Research showed that the composite …

The Morita–Baylis–Hillman reaction attracts significant attention for the synthesis of highly
functionalized compounds. It requires multiple catalytic elements for efficient catalysis …

Abstract BACKGROUND The Morita–Baylis–Hillman (MBH) reaction is an important carbon–
carbon bond‐forming reaction. However, most MBH reactions suffer disadvantages such as …