Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Abstract Purpose of Review The evolving information of the initiation, tumor cell
heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives …

Neuroblastoma is the most common extracranial solid tumor in infants, arising from
developmentally stalled neural crest-derived cells. Driving tumor differentiation is a …

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with
an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 …

Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of
DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF …

MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix
transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk …

Simple Summary The cancer genome has been exhaustively studied upon the advent of
Next-Generation Sequencing technologies. Coding and non-coding sequences have been …

Background The repressor element-1 silencing transcription factor (REST), a master
transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in …

In the past two decades, technological advances have brought unprecedented insights into
the paediatric cancer genome revealing characteristics distinct from those of adult cancer …

Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related
deaths in children. High-risk tumours are often difficult to treat, and patients' survival chances …