The Notch signaling pathway maintains a balance between cell proliferation and apoptosis,
and thus it is believed that Notch signaling pathway may play an important role in the …

The development of metastasis requires the movement and invasion of cancer cells from the
primary tumor into the surrounding tissue. To acquire such invasive abilities, epithelial …

This review provides a summary of our current understanding of, and the controversies
surrounding, the diagnosis, pathogenesis, histopathology, and molecular biology of Barrett's …

The E-box-binding zinc finger transcription factors Slug and ZEB1 are important repressors
of E-cadherin, contributing to epithelial–mesenchymal transition (EMT) in primary epithelial …

Epithelial-mesenchymal transition (EMT) is a highly conserved process that has been well
characterised in embryogenesis. Studies have shown that the aberrant activation of EMT in …

Background and aims Helicobacter pylori (H pylori) infection is a major risk factor in the
development of distal gastric adenocarcinoma. Development of the invasive phenotype is …

PURPOSE: Multidrug resistance is resistance to structurally unrelated anticancer agents.
Large-scale expression analysis by using high-density oligonucleotide microarrays may …

Background & Aims Metaplastic glands buried under squamous epithelium are frequently
detected in patients with Barrett esophagus (BE). This subsquamous intestinal metaplasia …

Abstract Background Slug, Snail, and Twist are transcription factors that regulate the
expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the …

Members of Snail family of transcription factors play an important role in oral cancer
progression by inducing epithelial–mesenchymal transition, by promoting invasion and by …