[HTML][HTML] Towards the functional high-resolution coordination chemistry of blood plasma human serum albumin
S Al-Harthi, JI Lachowicz, ME Nowakowski… - Journal of inorganic …, 2019 - Elsevier
Human serum albumin (HSA) is a monomeric, globular, multi-carrier and the most abundant
protein in the blood. HSA displays multiple ligand binding sites with extraordinary binding …
protein in the blood. HSA displays multiple ligand binding sites with extraordinary binding …
Normal mode analysis as a routine part of a structural investigation
JA Bauer, J Pavlović, V Bauerová-Hlinková - Molecules, 2019 - mdpi.com
Normal mode analysis (NMA) is a technique that can be used to describe the flexible states
accessible to a protein about an equilibrium position. These states have been shown …
accessible to a protein about an equilibrium position. These states have been shown …
[HTML][HTML] PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and
chronic diseases and executed via oxygenation of polyunsaturated …
chronic diseases and executed via oxygenation of polyunsaturated …
Decrypting Allostery in Membrane-Bound K-Ras4B Using Complementary In Silico Approaches Based on Unbiased Molecular Dynamics Simulations
M Castelli, F Marchetti, S Osuna… - Journal of the …, 2023 - ACS Publications
Protein functions are dynamically regulated by allostery, which enables conformational
communication even between faraway residues, and expresses itself in many forms, akin to …
communication even between faraway residues, and expresses itself in many forms, akin to …
[HTML][HTML] Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects …
TS Anthonymuthu, YY Tyurina, WY Sun… - Redox Biology, 2021 - Elsevier
Abstract Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a
ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX) …
ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX) …
LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor
Protein dynamics is central to all biological processes, including signal transduction, cellular
regulation and biological catalysis. Among them, in-depth exploration of ligand-driven …
regulation and biological catalysis. Among them, in-depth exploration of ligand-driven …
Rhapsody: predicting the pathogenicity of human missense variants
Motivation The biological effects of human missense variants have been studied
experimentally for decades but predicting their effects in clinical molecular diagnostics …
experimentally for decades but predicting their effects in clinical molecular diagnostics …
DynOmics: dynamics of structural proteome and beyond
Abstract DynOmics (dynomics. pitt. edu) is a portal developed to leverage rapidly growing
structural proteomics data by efficiently and accurately evaluating the dynamics of …
structural proteomics data by efficiently and accurately evaluating the dynamics of …
Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium
HH Dar, YY Tyurina… - The Journal of …, 2019 - Am Soc Clin Investig
Ferroptosis is a death program executed via selective oxidation of arachidonic acid–
phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues …
phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues …
Shared signature dynamics tempered by local fluctuations enables fold adaptability and specificity
Recent studies have drawn attention to the evolution of protein dynamics, in addition to
sequence and structure, based on the premise structure-encodes-dynamics-encodes …
sequence and structure, based on the premise structure-encodes-dynamics-encodes …