Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two
independently derived ENU-induced mutations in Exon 2 of mouse Disc1. Mice with …

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1)
genetically engineered mice as a potential model for major mental illnesses, such as …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …

BACKGROUND: Gene-environment interactions (GEI) are involved in the pathogenesis of
mental diseases. We evaluated interaction between mutant human disrupted-in …

Schizophrenia is a prevalent complex trait disorder manifested by severe neurocognitive
dysfunctions and lifelong disability. During the past few years several studies have provided …

A strong candidate gene for schizophrenia and major mental disorders, disrupted-in-
schizophrenia 1 (DISC1) was first described in a large Scottish family in which a balanced …

In the decade since Disrupted in Schizophrenia 1 (DISC1) was first identified it has become
one of the most convincing risk genes for major mental illness. As a multi-functional scaffold …

Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility
gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that …