Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are functional proteins and domains that devoid stable secondary and/or tertiary structure …

Although it is one of the most studied proteins, p53 continues to be an enigma. This protein
has numerous biological functions, possesses intrinsically disordered regions crucial for its …

The functional proteome of a given organism noticeably exceeds its corresponding genome
due to various events at the DNA (genetic variations), mRNA (alternative splicing, alternative …

A good portion of the 'protein universe'embodies the 'dark proteome'. The latter comprises
proteins not amenable to experimental structure determination by existing means and …

GPCR–G protein signaling system recognizes a multitude of extracellular ligands and
triggers a variety of intracellular signaling cascades in response. In humans, this system …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. However, biomarkers that require testing in the brain tissue pose …

Annexins and S100 proteins form two large families of Ca2+-binding proteins. They are
quite different both structurally and functionally, with S100 proteins being small (10–12 kDa) …

Pathological developments leading to amyotrophic lateral sclerosis (ALS) and
frontotemporal lobar degeneration (FTLD) are associated with misbehavior of several key …

Intrinsically disordered proteins (IDPs), which are functional proteins without stable tertiary
structure, and hybrid proteins containing ordered domains and intrinsically disordered …