Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a
decade ago, a large number of molecular and histopathologic studies were published that …

Ovarian cancer encompasses a collection of neoplasms with distinct clinicopathological and
molecular features and prognosis. Despite there being a variety of ovarian cancer subtypes …

Recent morphologic, immunohistochemical, and molecular genetic studies have led to the
development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer …

Background Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five
major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous …

Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier
system in which tumors are subdivided into low grade and high grade has been proposed …

Type I ovarian tumors, where precursor lesions in the ovary have clearly been described,
include endometrioid, clear cell, mucinous, low grade serous, and transitional cell …

The accepted view of ovarian carcinogenesis is that carcinoma begins in the ovary,
undergoes progressive" dedifferentiation" from a well to a poorly differentiated tumor, and …

Following cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic
cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen …

Background Ovarian cancer has the highest ratio of mortality among gynecologic
malignancies. Chemotherapy is one of the most common treatment options for ovarian …