[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …
Venetoclax and navitoclax in combination with chemotherapy in patients with relapsed or refractory acute lymphoblastic leukemia and lymphoblastic lymphoma
VA Pullarkat, NJ Lacayo, E Jabbour, JE Rubnitz… - Cancer discovery, 2021 - AACR
Combining venetoclax, a selective BCL2 inhibitor, with low-dose navitoclax, a BCL-XL/BCL2
inhibitor, may allow targeting of both BCL2 and BCL-XL without dose-limiting …
inhibitor, may allow targeting of both BCL2 and BCL-XL without dose-limiting …
Phyllanthin inhibits MOLT‐4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway
H Wang, A Chinnathambi, TA Alahmadi… - … of biochemical and …, 2021 - Wiley Online Library
Among cancers, leukemia is a multistep progression that involves genetic modifications of
normal hematopoietic progenitor cells to cancerous cells. In recent times, leukemia cases …
normal hematopoietic progenitor cells to cancerous cells. In recent times, leukemia cases …
The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines
Apigenin is a dietary polyphenol found abundantly in fruit and vegetables, which sensitizes
leukaemia cells to topoisomerase inhibitor agents (eg, etoposide), and alkylating agents (eg …
leukaemia cells to topoisomerase inhibitor agents (eg, etoposide), and alkylating agents (eg …
CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers
HR Jung, Y Oh, D Na, S Min, J Kang, D Jang, S Shin… - Oncogene, 2021 - nature.com
Metastatic or recurrent colorectal cancer (CRC) patients require systemic chemotherapy, but
the therapeutic options of targeted agents remain limited. CRC patients with KRAS or BRAF …
the therapeutic options of targeted agents remain limited. CRC patients with KRAS or BRAF …
MicroRNAs and the diagnosis of childhood acute lymphoblastic leukemia: systematic review, meta-analysis and re-analysis with novel small RNA-seq tools
Simple Summary MicroRNAs (miRNAs) have been under the spotlight for the last three
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …
Acute myeloid leukemia: from biology to clinical practices through development and pre-clinical therapeutics
X Roussel, E Daguindau, A Berceanu… - Frontiers in …, 2020 - frontiersin.org
Recent studies have provided several insights into acute myeloid leukemia. Studies based
on molecular biology have identified eight functional mutations involved in leukemogenesis …
on molecular biology have identified eight functional mutations involved in leukemogenesis …
The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors
Y Qiu, Y Li, M Chai, H Hua, R Wang, S Waxman… - Cell Death …, 2023 - nature.com
Acute myeloid leukemia (AML) patients with FLT3-ITD mutations are associated with poor
prognosis. FLT3-ITD inhibitors are developed and result in transient disease remission, but …
prognosis. FLT3-ITD inhibitors are developed and result in transient disease remission, but …
Mitochondria: a galaxy in the hematopoietic and leukemic stem cell universe
C Panuzzo, A Jovanovski, B Pergolizzi, L Pironi… - International journal of …, 2020 - mdpi.com
Mitochondria are the main fascinating energetic source into the cells. Their number, shape,
and dynamism are controlled by the cell's type and current behavior. The perturbation of the …
and dynamism are controlled by the cell's type and current behavior. The perturbation of the …