Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics

A Gabory, TJ Roseboom, T Moore, LG Moore… - Biology of sex …, 2013 - Springer
Sex differences occur in most non-communicable diseases, including metabolic diseases,
hypertension, cardiovascular disease, psychiatric and neurological disorders and cancer. In …

Human placental adaptive changes in response to maternal obesity: sex specificities

ED Santos, MH Hernández, V Sérazin… - International Journal of …, 2023 - mdpi.com
Maternal obesity is increasingly prevalent and is associated with elevated morbidity and
mortality rates in both mothers and children. At the interface between the mother and the …

Examining sex differences in the human placental transcriptome during the first fetal androgen peak

AE Braun, KL Muench, BG Robinson, A Wang… - Reproductive …, 2021 - Springer
Sex differences in human placenta exist from early pregnancy to term, however, it is unclear
whether these differences are driven solely by sex chromosome complement or are subject …

Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta

G Pidoux, P Gerbaud, M Cocquebert, N Segond… - Placenta, 2012 - Elsevier
The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of
numerous placental functions, including ion and nutrient exchange and the synthesis of …

Placenta accreta and placenta increta: an approach to pathogenesis based on the trophoblastic differentiation pathway

SF Cramer, DS Heller - Pediatric and Developmental …, 2016 - journals.sagepub.com
Morbid adherence remains a puzzling disease. This paper suggests that normal and
morbidly adherent placentation may be viewed best in terms of trophoblastic stem cells and …

Trypanosoma cruzi induces trophoblast differentiation: a potential local antiparasitic mechanism of the human placenta?

A Liempi, C Castillo, J Duaso, D Droguett, A Sandoval… - Placenta, 2014 - Elsevier
Introduction The congenital transmission of Trypanosoma cruzi (T. cruzi) is responsible for
one-third of new Chagas disease cases each year. During congenital transmission, the …

Trypanosoma cruzi induces apoptosis in ex vivo infected human chorionic villi

J Duaso, G Rojo, F Jaña, N Galanti, G Cabrera… - Placenta, 2011 - Elsevier
Chagas' disease, produced by the haemoflagellated protozoan Trypanosoma cruzi (T.
cruzi), is one of the most frequent endemic diseases in Latin America. In spite that in the past …

Downregulation of miR-29a/b/c in placenta accreta inhibits apoptosis of implantation site intermediate trophoblast cells by targeting MCL1

Y Gu, Y Bian, X Xu, X Wang, C Zuo, J Meng, H Li… - Placenta, 2016 - Elsevier
Objective Placenta accreta is defined as abnormal adhesion of placental villi to the uterine
myometrium. Although this condition has become more common as a result of the increasing …

Mechanism of Trypanosoma cruzi Placenta Invasion and Infection: The Use of Human Chorionic Villi Explants

RE Fretes, U Kemmerling - Journal of Tropical Medicine, 2012 - Wiley Online Library
Congenital Chagas disease, a neglected tropical disease, endemic in Latin America, is
associated with premature labor and miscarriage. During vertical transmission the parasite …

Downregulation of MicroRNA-125a in placenta accreta spectrum disorders contributes antiapoptosis of implantation site intermediate trophoblasts by targeting MCL1

Y Gu, J Meng, C Zuo, S Wang, H Li… - Reproductive …, 2019 - journals.sagepub.com
The typical hallmark of placenta accreta spectrum (PAS) disorders is increased implantation
site intermediate trophoblast (ISIT) cell numbers. However, the extent of trophoblast …