Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

Abstract Systems medicine (SM) has emerged as a powerful tool for studying the human
body at the systems level with the aim of improving our understanding, prevention and …

Rare genetic diseases are typically caused by a single gene defect. Despite this clear
causal relationship between genotype and phenotype, identifying the pathobiological …

Introduction The lack of biomarkers indicating involved nociceptive and/or pain mechanisms
makes diagnostic procedures problematic. Clinical pain research has begun to use …

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary
field that considers the human body as a system, composed of multiple parts and of complex …

Drug research, therapy development, and other areas of pharmacology and medicine can
benefit from simulations and optimization of mathematical models that contain a …

Omics data have been increasingly generated with limited demonstrated value in drug
safety assessment. The TransQST consortium was launched to use omics and other data in …

It has been suggested that alterations in inflammation molecules maintain chronic pain
although little is known about how these factors influence homeostatic and inflammatory …

In this work, the position of contemporary microbiology is considered from the perspective of
scientific success, and a list of historical points and lessons learned from the fields of …

With a widely attended virtual kickoff event on January 29, 2021, the National Cancer
Institute (NCI) and the Department of Energy (DOE) launched a series of 4 interactive …