Dynamic PET (dPET) studies have been used until now primarily within research purposes.
Although it is generally accepted that the information provided by dPET is superior to that of …

For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation,
most second-generation radioligands are sensitive to the single nucleotide polymorphism …

In central nervous system drug discovery programs, early development of new chemical
entities (NCEs) requires a multidisciplinary strategy and a translational approach to obtain …

Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method …

The purpose of the study was to evaluate the 6-[18F] fluoro-l-dopa (FDOPA) kinetics with
PET in patients with treated melanoma metastases and to compare it with the standard …

In molecular imaging modalities such as positron emission tomography (PET) or single
photon emission computed tomography (SPECT), parametric imaging is the process of …

This study examined D-amphetamine (D-AMPH)-induced displacements of [18 F] fallypride
in striatal and extrastriatal regions and the correlations of these displacements with …

BACKGROUND: Studies in schizophrenic patients have reported dopaminergic
abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and …

Clozapine and quetiapine have a low incidence of extrapyramidal side effects at clinically
effective doses, which appears to be related to their significantly lower occupancy of striatal …

The kinetic modeling of [11C]-(+)-PHNO binding to the dopamine D2/3 receptors in six
human volunteers using positron emission tomography (PET) is described.[11C]-(+)-PHNO …