Structure and function of enzymes of the Leloir pathway for galactose metabolism

HM Holden, I Rayment, JB Thoden - Journal of Biological Chemistry, 2003 - ASBMB
In most organisms, the conversion of-D-galactose to the more metabolically useful glucose 1-
phosphate is accomplished by the action of four enzymes that constitute the Leloir pathway …

Sulfoglycolysis: catabolic pathways for metabolism of sulfoquinovose

AJD Snow, L Burchill, M Sharma, GJ Davies… - Chemical Society …, 2021 - pubs.rsc.org
Sulfoquinovose (SQ), a derivative of glucose with a C6-sulfonate, is produced by
photosynthetic organisms and is the headgroup of the sulfolipid sulfoquinovosyl …

Phytophthora sojae apoplastic effector AEP1 mediates sugar uptake by mutarotation of extracellular aldose and is recognized as a MAMP

Y Xu, Y Zhang, J Zhu, Y Sun, B Guo, F Liu… - Plant …, 2021 - academic.oup.com
Diseases caused by Phytophthora pathogens devastate many crops worldwide. During
infection, Phytophthora pathogens secrete effectors, which are central molecules for …

The Intergenic Interplay between Aldose 1-Epimerase-Like Protein and Pectin Methylesterase in Abiotic and Biotic Stress Control

EV Sheshukova, TV Komarova… - Frontiers in plant …, 2017 - frontiersin.org
The mechanical damage that often precedes the penetration of a leaf by a pathogen
promotes the activation of pectin methylesterase (PME); the activation of PME leads to the …

Molecular structure of galactokinase

JB Thoden, HM Holden - Journal of Biological Chemistry, 2003 - ASBMB
Galactokinase plays a key role in normal galactose metabolism by catalyzing the ATP-
dependent phosphorylation of α-d-galactose to galactose 1-phosphate. In humans …

[HTML][HTML] Identification and characterisation of human aldose 1-epimerase

DJ Timson, RJ Reece - FEBS letters, 2003 - Elsevier
Aldose 1-epimerase or mutarotase (EC 5.1. 3.3) is a key enzyme of carbohydrate
metabolism catalysing the interconversion of the α-and β-anomers of hexose sugars such as …

The structural and molecular biology of type IV galactosemia

S Banford, DJ Timson - Biochimie, 2021 - Elsevier
Type IV galactosemia is a recently discovered inherited metabolic disease. It is caused by
mutations in the GALM gene which result in reduced activity of the enzyme galactose …

NMR application probes a novel and ubiquitous family of enzymes that alter monosaccharide configuration

KS Ryu, C Kim, I Kim, S Yoo, BS Choi, C Park - Journal of Biological …, 2004 - ASBMB
By exploiting nuclear magnetic resonance (NMR) techniques along with novel applications
of saturation difference analysis, we deciphered the functions of the previously …

The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae

JB Thoden, HM Holden - Journal of Biological Chemistry, 2005 - ASBMB
The metabolic pathway by which β-d-galactose is converted to glucose 1-phosphate is
known as the Leloir pathway and consists of four enzymes. In most organisms, these …

Molecular structure of human galactose mutarotase

JB Thoden, DJ Timson, RJ Reece… - Journal of Biological …, 2004 - ASBMB
Galactose mutarotase catalyzes the conversion of β-d-galactose to α-d-galactose during
normal galactose metabolism. The enzyme has been isolated from bacteria, plants, and …