Cis-regulatory sequences in plants: their importance, discovery, and future challenges
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …
function to coordinate responses to developmental and environmental cues is of paramount …
LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond
DNA methylation is one of the most important epigenetic mechanisms to regulate gene
expression, which is highly dynamic during development and specifically maintained in …
expression, which is highly dynamic during development and specifically maintained in …
Dynamics and function of DNA methylation in plants
DNA methylation is a conserved epigenetic modification that is important for gene regulation
and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental …
and genome stability. Aberrant patterns of DNA methylation can lead to plant developmental …
Prediction of protein–ligand binding affinity from sequencing data with interpretable machine learning
Protein–ligand interactions are increasingly profiled at high throughput using affinity
selection and massively parallel sequencing. However, these assays do not provide the …
selection and massively parallel sequencing. However, these assays do not provide the …
Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Environmental influences on the epigenome: exposure-associated DNA methylation in human populations
EM Martin, RC Fry - Annual review of public health, 2018 - annualreviews.org
DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …
environmental exposures. To date, numerous studies have detailed the manner by which …
Intrinsic mechanisms of neuronal axon regeneration
M Mahar, V Cavalli - Nature Reviews Neuroscience, 2018 - nature.com
Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …
regenerate and rebuild functional connections with their original targets. By contrast, injury …
[HTML][HTML] Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …
However, it is frequently dysregulated during tumor development and is closely intertwined …
Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …