Overcoming the translational crisis of contemporary psychiatry–converging phenomenological and spatiotemporal psychopathology

G Northoff, J Daub, D Hirjak - Molecular Psychiatry, 2023 - nature.com
Despite all neurobiological/neurocomputational progress in psychiatric research, recent
authors speak about a 'crisis of contemporary psychiatry'. Some argue that we do not yet …

Seasonality of brain function: role in psychiatric disorders

R Zhang, ND Volkow - Translational Psychiatry, 2023 - nature.com
Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders

B Conio, M Martino, P Magioncalda, A Escelsior… - Molecular …, 2020 - nature.com
Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …

How do the brain's time and space mediate consciousness and its different dimensions? Temporo-spatial theory of consciousness (TTC)

G Northoff, Z Huang - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Time and space are the basic building blocks of nature. As a unique existent in nature, our
brain exists in time and takes up space. The brain's activity itself also constitutes and …

All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders

G Northoff, D Hirjak, RC Wolf, P Magioncalda… - Molecular …, 2021 - nature.com
Psychomotor abnormalities have been abundantly observed in psychiatric disorders like
major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCH). Although …

Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies

B Bi, D Che, Y Bai - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in
three domains including emotional processing, cognitive processing, and psychomotor …

[HTML][HTML] Spatiotemporal neuroscience–what is it and why we need it

G Northoff, S Wainio-Theberge, K Evers - Physics of life reviews, 2020 - Elsevier
The excellent commentaries to our target paper hint upon three main issues,(i)
spatiotemporal neuroscience;(ii) neuro-mental relationship; and (iii) mind, brain, and world …

A unified model of the pathophysiology of bipolar disorder

P Magioncalda, M Martino - Molecular Psychiatry, 2022 - nature.com
This work provides an overview of the most consistent alterations in bipolar disorder (BD),
attempting to unify them in an internally coherent working model of the pathophysiology of …

Endless fluctuations: temporal dynamics of the amplitude of low frequency fluctuations

W Liao, J Li, GJ Ji, GR Wu, Z Long, Q Xu… - … on Medical Imaging, 2019 - ieeexplore.ieee.org
Intrinsic neural activity ubiquitously persists in all physiological states. However, how
intrinsic brain activity (iBA) changes over a short time remains unknown. To uncover the …