The biology and function of extracellular vesicles in immune response and immunity

R Kalluri - Immunity, 2024 - cell.com
Extracellular vesicles (EVs), such as ectosomes and exosomes, contain DNA, RNA, proteins
and are encased in a phospholipid bilayer. EVs provide intralumenal cargo for delivery into …

Extracellular vesicles in fungi: past, present, and future perspectives

J Rizzo, ML Rodrigues, G Janbon - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical
research fields. Many studies have reported the existence of EVs in all types of living cells …

[HTML][HTML] Invasive fungal disease in humans: are we aware of the real impact?

C Firacative - Memórias do Instituto Oswaldo Cruz, 2020 - SciELO Brasil
Despite the medical advances and interventions to improve the quality of life of those in
intensive care, people with cancer or severely immunocompromised or other susceptible …

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3 …

JA Maertens, II Raad, KA Marr, TF Patterson… - The Lancet, 2016 - thelancet.com
Background Isavuconazole is a novel triazole with broad-spectrum antifungal activity. The
SECURE trial assessed efficacy and safety of isavuconazole versus voriconazole in patients …

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

J Rizzo, SSW Wong, AD Gazi… - Journal of …, 2021 - Wiley Online Library
Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

[HTML][HTML] Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy

J Wu, T Ma, M Zhu, T Huang, B Zhang, J Gao, N Lin - Nano Today, 2022 - Elsevier
Misguided attack of immune systems on self-tissue or multifactorial uncontrolled
inflammation is capable of causing inflammatory diseases. Neutrophils play a critical role in …

The functional heterogeneity of neutrophil-derived extracellular vesicles reflects the status of the parent cell

F Kolonics, V Szeifert, CI Timár, E Ligeti, ÁM Lőrincz - Cells, 2020 - mdpi.com
Similar to other cell types, neutrophilic granulocytes also release extracellular vesicles
(EVs), mainly medium-sized microvesicles/microparticles. According to published data …

The Interactions Between Candida albicans and Mucosal Immunity

Y Zhou, L Cheng, YL Lei, B Ren, X Zhou - Frontiers in microbiology, 2021 - frontiersin.org
Mucosa protects the body against external pathogen invasion. However, pathogen colonies
on the mucosa can invade the mucosa when the immunosurveillance is compromised …

Efficient neutrophil activation requires two simultaneous activating stimuli

S Mol, FMJ Hafkamp, L Varela, N Simkhada… - International journal of …, 2021 - mdpi.com
Neutrophils are abundantly present in the synovium and synovial fluid of patients suffering
from arthritis. Neutrophils can be activated by a multitude of stimuli and the current dogma …