Recent advances in antimalarial drug development

S Vangapandu, M Jain, K Kaur, P Patil… - Medicinal research …, 2007 - Wiley Online Library
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence,
and drug resistance, is the most serious and widespread parasitic disease encountered by …

Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5 …

N Singh, G Cheve, MA Avery… - Current pharmaceutical …, 2007 - ingentaconnect.com
The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview

PJ Proteau - Bioorganic chemistry, 2004 - Elsevier
The methylerythritol phosphate pathway to isoprenoids, an alternate biosynthetic route
present in many bacteria, algae, plants, and the malarial parasite Plasmodium falciparum …

Isoprenoid biosynthesis of the apicoplast as drug target

J Wiesner, H Jomaa - Current drug targets, 2007 - ingentaconnect.com
In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-
independent 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP …

Cytokinin nucleosides-natural compounds with a unique spectrum of biological activities

M S. Drenichev, V E. Oslovsky… - Current topics in …, 2016 - benthamdirect.com
Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing,
anti-inflammatory, and antipsychotic activity. These compounds also influence platelet …

Comprehensive survey of combinatorial library synthesis: 2004

RE Dolle - Journal of combinatorial chemistry, 2005 - ACS Publications
Comprehensive Survey of Combinatorial Library Synthesis: 2004 | ACS Combinatorial Science
ACS ACS Publications C&EN CAS Find my institution Log In Journal of Combinatorial Chemistry …

N-Acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry

P Heidler, A Link - Bioorganic & medicinal chemistry, 2005 - Elsevier
In 1971 Kenner et al. introduced the safety-catch principle into solid phase peptide
synthesis. Thus two contradicting needs were addressed. On the one hand, sufficient …

High-throughput five minute microwave accelerated glycosylation approach to the synthesis of nucleoside libraries

BC Bookser, NB Raffaele - The Journal of Organic Chemistry, 2007 - ACS Publications
The Vorbrüggen glycosylation reaction was adapted into a one-step 5 min/130° C
microwave assisted reaction. Triethanolamine in acetontrile containing 2% water was …

Chemical modification of the plant isoprenoid cytokinin N6-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication

VI Tararov, A Tijsma, SV Kolyachkina… - European Journal of …, 2015 - Elsevier
In this study, we demonstrate that N 6-isopentenyladenosine, which essentially is a plant
cytokinin-like compound, exerts a potent and selective antiviral effect on the replication of …

Towards New Antimalarial Drugs: Synthesis of Non‐Hydrolyzable Phosphate Mimics as Feed for a Predictive QSAR Study on 1‐Deoxy‐D‐xylulose‐5‐phosphate …

D Gießmann, P Heidler, T Haemers… - Chemistry & …, 2008 - Wiley Online Library
The conversion of 1‐deoxy‐d‐xylulose‐5‐phosphate (DOXP) to 2‐C‐methyl‐d‐erythritol‐4‐
phosphate (MEP) is effectively blocked by 1‐deoxy‐d‐xylulose‐5‐phosphate …