Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …

In the messenger RNA (mRNA) maturation process, the 3′‐end of pre‐mRNA is cleaved
and a poly (A) sequence is added, this is an important determinant of mRNA stability and its …

Alternative polyadenylation (APA) creates distinct transcripts from the same gene by
cleaving the pre-mRNA at poly (A) sites that can lie within the 3′ untranslated region (3 …

The aim of this study was to find the application value of selective polyadenylation in
immune cell infiltration, biological transcription function and risk assessment of survival and …

Introduction Lipid metabolic reprogramming is gaining attention as a hallmark of cancers.
Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is …

Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …

Platinum-based chemotherapy is the standard postoperative adjuvant treatment for ovarian
cancer (OC). Despite the initial response to chemotherapy, 85% of advanced OC patients …

Alternative cleavage and polyadenylation (APA) often results in production of mRNA
isoforms with either longer or shorter 3′ UTRs from the same genetic locus, potentially …

Two major posttranscriptional mechanisms—alternative splicing (AS) and alternative
polyadenylation (APA)—have attracted much attention in cancer research. Nevertheless …

Alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism; yet, its
regulation and impact on human diseases remain understudied. Existing bulk RNA …