The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …

The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor
tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3 …

Introduction: Carcinoma of the breast is the most common malignancy of women in Karachi.
The currentstudy was conducted with the objective of assessing estrogen receptor (ER) …

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to
stimulate the growth of a variety of cells in an autocrine or paracrine manner. Although HB …

Background The aim of this study is to provide an expression profile of ErbB/HER ligands in
breast cancer. We analysed the relationships with their receptors, the bio-pathological …

TRIM11 (tripartite motif-containing protein 11), an E3 ubiquitin ligase, is known to be
involved in the development of the central nervous system. However, very little is known …

The first part of this two-part review of established and emerging breast cancer biomarkers
and molecular diagnostics considers breast cancer predisposition, screening tests for …

Background Tumor-associated macrophages (TAM) promote malignant progression, yet the
repertoire of oncogenic factors secreted by TAM has not been clearly defined. We sought to …

A protease is an enzyme with a proteolytic activity that facilitates the digestion of its
substrates. Membrane-type I matrix metalloproteinase (MT1-MMP), a member of the broader …

The growth factor heregulin (HRG), a ligand of ErbB3 and ErbB4 receptors, contributes to
breast cancer development and the promotion of metastatic disease, and its expression in …