The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces
various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in …

Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

Vimentin is a Type III intermediate filament (VIF) cytoskeletal protein that regulates the
mechanical and migratory behavior of cells. Its expression is considered to be a marker for …

The metastatic cascade presents a significant challenge to patient survival in the fight
against cancer. As metastatic cells disseminate and colonize a secondary site, stepwise …

Since the crucial role of the microenvironment has been highlighted, many studies have
been focused on the role of biomechanics in cancer cell growth and the invasion of the …

Hepatocellular carcinoma (HCC) cells, especially those with metastatic competence, show
reduced stiffness compared to the non-malignant counterparts. However, it is still unclear …

Stiffening of the extracellular matrix (ECM) is considered a typical remolding of the
microenvironment in multistep tumor progression. However, the molecular mechanisms by …

Cellular mechanical properties (eg compressibility) are important biophysical markers in
relation to cellular processes and functionality. Among the methods for cell mechanical …

The elucidation of biomechanics furthers our understanding of brain tumour biology.
Brillouin spectroscopy is a new optical method that addresses viscoelastic properties down …