Endothelial mechanotransduction, redox signaling and the regulation of vascular inflammatory pathways

S Chatterjee - Frontiers in physiology, 2018 - frontiersin.org
The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The
shear stress arising from blood flow is “sensed” by the endothelium and is “transduced” into …

Hemodynamics and complications encountered with arteriovenous fistulas and grafts as vascular access for hemodialysis: a review

I Van Tricht, D De Wachter, J Tordoir… - Annals of biomedical …, 2005 - Springer
This review article describes the current state of affairs concerning in vivo, in vitro and in
numero studies on the hemodynamics in vascular access for hemodialysis. The use and …

A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics

A Corti, M Colombo, JM Rozowsky… - Journal of the …, 2022 - royalsocietypublishing.org
In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …

Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications

B Wu, G Mottola, M Schaller, GR Upchurch Jr… - Molecular aspects of …, 2017 - Elsevier
Acute vascular injury occurs in a number of important clinical contexts, including
spontaneous disease-related events (eg plaque rupture, thrombosis) and therapeutic …

[HTML][HTML] Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch

JW Tierney, BC Evans, J Cheung-Flynn, B Wang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to
intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) …

Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: effects of tissue damage and hemodynamics on cellular activity

A Corti, M Colombo, F Migliavacca, SA Berceli… - Computers in Biology …, 2022 - Elsevier
Background Restenosis following percutaneous transluminal angioplasty (PTA) in femoral
arteries is a major cause of failure of the revascularization procedure. The arterial wall …

[HTML][HTML] Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model

B Wu, EC Werlin, M Chen, G Mottola… - Journal of vascular …, 2018 - Elsevier
Objective Inflammation is a key driver of excessive neointimal hyperplasia within vein grafts.
Recent work demonstrates that specialized proresolving lipid mediators biosynthesized from …

[HTML][HTML] Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts

H Banno, Y Takei, T Muramatsu, K Komori… - Journal of Vascular …, 2006 - Elsevier
OBJECTIVE: Intimal hyperplasia is a major obstacle to patency after vein grafting. Despite of
a diverse array of trials to prevent it, a satisfactory therapeutic strategy for clinical use has not …

Bioerodible wraps and uses therefor

MS El-Kurdl, Y Hong, L Soletti, JJ Stankus… - US Patent …, 2016 - Google Patents
A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber
matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may …

Computational evaluation of venous graft geometries in coronary artery bypass surgery

J Seo, AB Ramachandra, J Boyd, AL Marsden… - Seminars in thoracic and …, 2022 - Elsevier
Cardiothoracic surgeons are faced with a choice of different revascularization techniques
and diameters for saphenous vein grafts (SVG) in coronary artery bypass graft surgery …