Mechanism of action of ribosomally synthesized and post-translationally modified peptides
C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …
product class that has undergone significant expansion due to the rapid growth in genome …
Introduction to thiopeptides: biological activity, biosynthesis, and strategies for functional reprogramming
AA Vinogradov, H Suga - Cell Chemical Biology, 2020 - cell.com
Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …
Bacterial Cytochrome P450 Catalyzed Post‐translational Macrocyclization of Ribosomal Peptides
Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …
fascinating group of natural products that exhibit diverse structural features and bioactivities …
Radical SAM-dependent ether crosslink in daropeptide biosynthesis
Darobactin is a ribosomally synthesized and post-translationally modified peptide (RiPP),
which possesses potent activity against various Gram-negative bacteria. Darobactin features …
which possesses potent activity against various Gram-negative bacteria. Darobactin features …
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ …
GA Hudson, BJ Burkhart, AJ DiCaprio… - Journal of the …, 2019 - ACS Publications
Recently developed bioinformatic tools have bolstered the discovery of ribosomally
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …
The biosynthetic landscape of triceptides reveals radical SAM enzymes that catalyze cyclophane formation on Tyr-and His-containing motifs
Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …
peptides with several examples of pharmaceutical importance. Although both synthetic and …
Post-translational formation of strained cyclophanes in bacteria
Cyclic peptide natural products have served as important drug molecules, with several
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …
Bioinformatic expansion and discovery of thiopeptide antibiotics
Thiopeptides are members of the ribosomally synthesized and post-translationally modified
peptide family of natural products. Most characterized thiopeptides display nanomolar …
peptide family of natural products. Most characterized thiopeptides display nanomolar …
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation
Two of nature's recurring binding motifs in metalloproteins are the CxxxCxxC motif in radical
SAM enzymes and the 2-His-1-carboxylate motif found both in zincins and α-ketoglutarate …
SAM enzymes and the 2-His-1-carboxylate motif found both in zincins and α-ketoglutarate …
Atlas of the radical SAM superfamily: divergent evolution of function using a “plug and play” domain
GL Holliday, E Akiva, EC Meng, SD Brown… - Methods in …, 2018 - Elsevier
The radical SAM superfamily contains over 100,000 homologous enzymes that catalyze a
remarkably broad range of reactions required for life, including metabolism, nucleic acid …
remarkably broad range of reactions required for life, including metabolism, nucleic acid …