Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Cell–cell interactions define a quintessential aspect of multicellular development. Metazoan
morphogenesis depends on a handful of fundamental, conserved cellular interaction …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Vascular endothelial growth factor (VEGF) is essential for developmental and pathological
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF …

Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene,
rumi, with a temperature-sensitive Notch phenotype. At 28° C–30° C, rumi clones exhibit a …

We have identified Rabconnectin-3α and β (Rbcn-3A and B) as two regulators of Notch
signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in …