Efficacy, adverse events, and challenges of dienogest in the management of symptomatic adenomyosis: a comparison with different hormonal treatments

H Kobayashi - Gynecologic and Obstetric Investigation, 2023 - karger.com
Background: Adenomyosis is an estrogen-dependent gynecologic condition that can cause
pain symptoms, heavy menstrual bleeding, and infertility. Several treatments, including …

[PDF][PDF] Unopposed estrogens: current and future perspectives.

MM Oliva, R Gambioli, G Forte, G Porcaro… - European Review for …, 2022 - researchgate.net
Estrogens and progestogens act on female reproductive tissues in opposite ways. As they
counteract each other actions, the correct balance between these two classes of hormones …

[HTML][HTML] The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis

T Harada, F Taniguchi, SW Guo, YM Choi… - … Medicine and Biology, 2023 - ncbi.nlm.nih.gov
First described nearly two centuries ago, adenomyosis remains to this day a huge clinical
challenge due to its complex symptomology, enigmatic pathogenesis, and pathophysiology …

Comparison of dienogest versus combined oral contraceptive pills in the treatment of women with adenomyosis: A randomized clinical trial

AI Hassanin, AA Youssef, AM Yousef… - International Journal of …, 2021 - Wiley Online Library
Objective To compare the efficacy and safety of dienogest with combined oral contraceptives
(COCs) for treating adenomyosis‐associated symptoms. Methods This was a randomized …

Ulipristal acetate use in adenomyosis: A randomized controlled trial

P Capmas, JL Brun, G Legendre, M Koskas… - Journal of Gynecology …, 2021 - Elsevier
Objective To evaluate the effect of a 10 mg per day 12 week treatment of ulipristal acetate
(UPA) on abnormal uterine bleeding due to adenomyosis. Design A double-blind phase 2 …

Percutaneous cryoablation of symptomatic uterine adenomyomas: initial experience

C Marcelin, JL Brun, J Caprais, I Molina-Andreo… - Journal of Gynecology …, 2024 - Elsevier
Objective To assess the efficacy and safety of percutaneous image-guided cryoablation of
adenomyomas Material and Methods Five symptomatic women who wanted to preserve …

Transcriptome analysis of eutopic endometrial stromal cells in women with adenomyosis by RNA-sequencing

L Gan, Y Li, Y Chen, M Huang, J Cao, M Cao… - …, 2022 - Taylor & Francis
This study aimed to identify differentially expressed genes (DEGs) and molecular pathways
in eutopic endometrial stromal cells (EuESCs) from adenomyosis (AM) patients and to …

Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis

M Qu, P Lu, K Bellve, LM Lifshitz, R ZhuGe - Frontiers in Physiology, 2021 - frontiersin.org
Adenomyosis is a debilitating gynecological disease of the uterus with no medicinal cure.
The tissue injury and repair hypothesis for adenomyosis suggests that uterine …

[HTML][HTML] Clinical practice guidelines for endometriosis in Japan (The 3rd edition)

T Harada, F Taniguchi, M Kitajima… - The Journal of …, 2022 - ncbi.nlm.nih.gov
More than 10 years following the publication of “The General Rules for Clinical Management
of Endometriosis: The second edition” in January 2010, the longawaited third edition has …

Levonorgestrel-releasing intrauterine system improves menorrhagia-related quality of life in patients with symptomatic adenomyosis

C Ishizawa, Y Hirota, R Iida, T Kaku, T Hirata… - Reproductive …, 2023 - Springer
Levonorgestrel-releasing intrauterine system (LNG-IUS) relieves dysmenorrhea and heavy
menstrual bleeding (HMB) in adenomyosis. However, its efficacy on health-related quality of …