In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review

SMA Kawsar, NS Munia, S Saha… - Mini Reviews in …, 2024 - benthamdirect.com
Nucleoside analogs have been widely used as antiviral, antitumor, and antiparasitic agents
due to their ability to inhibit nucleic acid synthesis. Adenosine, cytidine, guanosine …

New developments in nucleoside analogues biosynthesis: A review

MJ Lapponi, CW Rivero, MA Zinni, CN Britos… - Journal of Molecular …, 2016 - Elsevier
The present review deals with current advances in the chemoenzymatic synthesis of
biologically important nucleoside analogues (NA), either by the use of microorganisms or …

Biocatalytic approaches applied to the synthesis of nucleoside prodrugs

LE Iglesias, ES Lewkowicz, R Medici, P Bianchi… - Biotechnology …, 2015 - Elsevier
Nucleosides are valuable bioactive molecules, which display antiviral and antitumour
activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy …

New insights on nucleoside 2′-deoxyribosyltransferases: a versatile biocatalyst for one-pot one-step synthesis of nucleoside analogs

A Fresco-Taboada, I De La Mata, M Arroyo… - Applied microbiology …, 2013 - Springer
In recent years, glycosiltransferases have arisen as standard biocatalysts for the enzymatic
synthesis of a wide variety of natural and non-natural nucleosides. Such enzymatic …

[HTML][HTML] Biotechnological applications of purine and pyrimidine deaminases

J Del Arco, J Acosta, J Fernández-Lucas - Biotechnology Advances, 2024 - Elsevier
Deaminases, ubiquitous enzymes found in all living organisms from bacteria to humans,
serve diverse and crucial functions. Notably, purine and pyrimidine deaminases, while …

Magnetic chitosan beads for covalent immobilization of nucleoside 2′-deoxyribosyltransferase: application in nucleoside analogues synthesis

J Fernández-Lucas, R Harris… - Journal of Industrial …, 2013 - academic.oup.com
Cross-linked magnetic chitosan beads were prepared in presence of epichlorohydrin under
alkaline conditions, and subsequently incubated with glutaraldehyde in order to obtain an …

Enzymatic synthesis of nucleoside analogues using immobilized 2′-deoxyribosyltransferase from Lactobacillus reuteri

J Fernández-Lucas, A Fresco-Taboada… - Applied microbiology …, 2011 - Springer
Covalent attachment of recombinant Lactobacillus reuteri 2′-deoxyribosyltransferase to
Sepabeads EC-EP303 leads to the immobilized biocatalyst S Lr NDT4, which displayed an …

Highly efficient and regioselective acylation of pharmacologically interesting cordycepin catalyzed by lipase in the eco-friendly solvent 2-methyltetrahydrofuran

ZG Chen, DN Zhang, L Cao, YB Han - Bioresource technology, 2013 - Elsevier
A total of nine lipases and three proteases were tested for enzymatic regioselective acylation
(s) of cordycepin with vinyl acetate in organic media. The highest conversion with better …

Enantio‐, regio‐, and chemoselective lipase‐catalyzed polymer synthesis

J Yang, Y Liu, X Liang, Y Yang… - Macromolecular …, 2018 - Wiley Online Library
In contrast to chemical routes, enzymatic polymerization possesses favorable characteristics
of mild reaction conditions, few by‐products, and high activity toward cyclic lactones which …

Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy

L Xu, X Liu, Y Li, Z Yin, L Jin, L Lu, J Qu… - Applied microbiology and …, 2019 - Springer
The synthesis of rhamnosylated compounds has gained great importance since these
compounds have potential therapeutic applications. The enzymatic approaches for …