Pain and immunity: implications for host defence
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
Nociceptor sensory neuron–immune interactions in pain and inflammation
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …
[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization
O Gouin, K L'herondelle, N Lebonvallet… - Protein & …, 2017 - academic.oup.com
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …
[HTML][HTML] Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …
TRPA1 as a therapeutic target for nociceptive pain
D Souza Monteiro de Araujo, R Nassini… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease
MS Steinhoff, B von Mentzer, P Geppetti… - Physiological …, 2014 - journals.physiology.org
The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …
neuropeptide families. They comprise a series of structurally related peptides that derive …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
The peripheral nervous and immune systems are traditionally thought of as serving separate
functions. The line between them is, however, becoming increasingly blurred by new …
functions. The line between them is, however, becoming increasingly blurred by new …