Small molecule tyrosine kinase inhibitors (TKIs) are widely used as anticancer drugs
approved by US FDA. However, the toxicities of TKIs to multiple organs have greatly limited …

Background Benzbromarone is a uricosuric drug that has been used in the treatment of gout
over the last 30 years. Due to its potent inhibition of the dominant apical (luminal) urate …

Emerging contaminants, as a group of trace contaminants arising from pharmaceuticals,
personal care products, etc., are of growing concern due to their potential hazard to the …

Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to
be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins …

Drug-induced agranulocytosis is a life-threatening side effect that usually manifests as a
severe form of neutropenia associated with fever or signs of sepsis. It can occur as a …

Evodiamine (EVD), which has been reported to cause liver damage, is the main constituent
of Evodia rutaecarpa (Juss.) Benth and may be bioactivated into reactive metabolites …

The targeted regulation of LSD1, which is highly expressed in a variety of tumor cells, is a
promising cancer therapy strategy. Several LSD1 inhibitors are currently under clinical …

The incidence of hyperuricemia and gout has been increasing year by year, and it is
showing a younger trend. However, the first-line drugs currently used for hyperuricemia and …

Abstract Context Lycium barbarum L.(Solanaceae) polysaccharides (LBPs) are important
active constituents that have demonstrated kidney protection. Objective This study …

Aim Despite the great efficacy reported for cisplatin as a widely used chemotherapeutic
agent, its clinical use is limited by the challenge of facing its serious side effect; …