Epstein–Barr virus (EBV) was first discovered in 1964, and was the first known human tumor
virus now shown to be associated with a vast number of human diseases. Numerous studies …

Upon primary infection, EBV establishes a latent infection in B cells, characterized by
maintenance of the viral genome in the absence of viral replication. The Epstein-Barr …

Relatively little is known about immune evasion during the productive phase of infection by
the γ1-herpesvirus Epstein–Barr virus (EBV). The use of a unique system to isolate cells in …

EBV, a member of the herpes virus family, is a paradigm for human tumor viruses and a
model of viral latency amenable for study in vitro. It induces resting human B lymphocytes to …

The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is one of the earliest viral proteins
expressed after infection and is the only latent protein consistently expressed in viral …

DNA methylation is the major modification of eukaryotic genomes and plays an essential
role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG) …

During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that has three general stages: immediate early (IE), early (E), and late (L) …

Epstein–Barr virus (EBV) is an extremely efficient virus infecting the majority of the world's
adult population (Rickinson and Kieff, 2001). Following primary infection, EBV persists in the …

The lytic form of EBV infection is required for the production of progeny virus, and is thus
essential for cell-to-cell spread of the virus, as well as transmission from host to host …

During lytic replication, herpesviruses express their genes in a temporal cascade
culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta-and …