Structural characterization of the millennial antibacterial (fluoro) quinolones—shaping the fifth generation

A Rusu, IA Lungu, OL Moldovan, C Tanase, G Hancu - Pharmaceutics, 2021 - mdpi.com
The evolution of the class of antibacterial quinolones includes the introduction in therapy of
highly successful compounds. Although many representatives were withdrawn due to …

Ophthalmic nano-bioconjugates: critical challenges and technological advances

SN Sanap, AC Bisen, S Agrawal, A Kedar… - Therapeutic …, 2023 - Taylor & Francis
Ophthalmic disease can cause permanent loss of vision and blindness. Easy-to-administer
topical and systemic treatments are preferred for treating sight-threatening disorders. Typical …

Investigating the effectiveness of difluprednate-loaded core-shell lipid-polymeric hybrid nanoparticles for ocular delivery

B Kaviarasi, N Rajana, YS Pooja… - International Journal of …, 2023 - Elsevier
Uveitis is a sight-threatening disease that causes inflammation in the uvea; difluprednate
(DFB) is the first approved drug molecule for postoperative pain, inflammation, and …

Formulation and evaluation of moxifloxacin loaded bilosomes in-situ gel: optimization to antibacterial evaluation

A Zafar, OA Alsaidan, SS Imam, M Yasir, KS Alharbi… - Gels, 2022 - mdpi.com
In this study, moxifloxacin (MX)-loaded bilosome (BS) in situ gel was prepared to improve
ocular residence time. MX-BSs were prepared using the thin-film hydration method. They …

Lipid-based nanocarriers for ocular drug delivery: An updated review

B Das, AK Nayak, S Mallick - Journal of Drug Delivery Science and …, 2022 - Elsevier
Recent years have witnessed a boom in ocular nanomedicine research with a number of
lipid-based nanocarriers such as liposomes, niosomes, cubosomes, nanoemulsions, solid …

Topical drug delivery to the retina: obstacles and routes to success

T Loftsson - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Retinal diseases are one of the main reasons for vision loss where all available
drug treatments are based on invasive drug administration such as intravitreal injections …

Lipid-based nanocarriers as topical drug delivery systems for intraocular diseases

J Navarro-Partida, CR Castro-Castaneda… - Pharmaceutics, 2021 - mdpi.com
Effective drug delivery to intraocular tissues remains a great challenge due to complex
anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To …

Pharmaceutical Emulsions: A Viable Approach for Ocular Drug Delivery

AC Bisen, S Srivastava, A Mishra… - Journal of Ocular …, 2024 - liebertpub.com
Ocular disorders can lead to serious sight impairment and irreversible blindness. Generally
simple topical and systemic treatments are recommended for treating these vision …

Development of ciprofloxacin-loaded bilosomes in-situ gel for ocular delivery: optimization, in-vitro characterization, ex-vivo permeation, and antimicrobial study

OA Alsaidan, A Zafar, M Yasir, SI Alzarea, M Alqinyah… - Gels, 2022 - mdpi.com
Conventional eye drops are most commonly employed topically in the eye for the
management of bacterial conjunctivitis. Eye drops have a low corneal residence time and 90 …

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization

R Zhang, J Yang, Q Luo, J Shi, H Xu, J Zhang - Drug Delivery, 2022 - Taylor & Francis
Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential
for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted …