[HTML][HTML] The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: a calcium dyshomeostasis perspective

D Lim, L Tapella, G Dematteis, AA Genazzani… - Ageing research …, 2023 - Elsevier
Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …

[HTML][HTML] Organelle mapping in dendrites of human iPSC-derived neurons reveals dynamic functional dendritic Golgi structures

J Wang, M Daniszewski, MM Hao, D Hernández… - Cell Reports, 2023 - cell.com
Secretory pathways within dendrites of neurons have been proposed for local transport of
newly synthesized proteins. However, little is known about the dynamics of the local …

Unraveling the multifaceted role of the golgi apparatus: insights into neuronal plasticity, development, neurogenesis, Alzheimer's disease, and SARS-CoV-2 …

C Toader, L Eva, RA Covache-Busuioc, HP Costin… - Brain Sciences, 2023 - mdpi.com
This article critically evaluates the multifunctional role of the Golgi apparatus within
neurological paradigms. We succinctly highlight its influence on neuronal plasticity …

[HTML][HTML] The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression

GI Corsi, VP Gadekar, H Haukedal, NT Doncheva… - Neurobiology of …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive and irreversible brain disorder, which can occur
either sporadically, due to a complex combination of environmental, genetic, and epigenetic …

Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in …

C Salcedo, V Pozo Garcia… - Journal of …, 2023 - Wiley Online Library
Glutamate recycling between neurons and astrocytes is essential to maintain
neurotransmitter homeostasis. Disturbances in glutamate homeostasis, resulting in …

RNA scaffolds the Golgi ribbon by forming condensates with GM130

Y Zhang, J Seemann - Nature cell biology, 2024 - nature.com
The mammalian Golgi is composed of stacks that are laterally connected into a continuous
ribbon-like structure. The integrity and function of the ribbon is disrupted under stress …

Spatial–Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP …

J Wang, PA Gleeson, L Fourriere - Traffic, 2024 - Wiley Online Library
Alzheimer's disease is associated with increased levels of amyloid beta (Aβ) generated by
sequential intracellular cleavage of amyloid precursor protein (APP) by membrane‐bound …

[HTML][HTML] Early signs of neurodegenerative diseases: Possible mechanisms and targets for Golgi stress

M Liu, Y Duan, J Dong, K Zhang, X Jin, M Gao… - Biomedicine & …, 2024 - Elsevier
The Golgi apparatus plays a crucial role in mediating the modification, transport, and sorting
of intracellular proteins and lipids. The morphological changes occurring in the Golgi …

[HTML][HTML] Targeted drug delivery system for Golgi apparatus's diseases

Y Xu, Y Jin, Y Huang, Y Wen, Z Gu, Y Zhu - Engineered Regeneration, 2024 - Elsevier
Golgi apparatus (GA) is an organelle widely present in eukaryotic cells and involved in a
variety of cellular physiological activities, including but not limited to protein modification and …

[HTML][HTML] Glycosylation in aging and neurodegenerative diseases: Glycosylation in aging and neurodegeneration

W Zhang, T Chen, H Zhao… - Acta Biochimica et …, 2024 - pmc.ncbi.nlm.nih.gov
Aging, a complex biological process, involves the progressive decline of physiological
functions across various systems, leading to increased susceptibility to neurodegenerative …