Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review
S Wadler, EL Schwartz - Cancer Research, 1990 - AACR
The combination of Interferon (IFN) and conventional chemotherapeutic agents offers a
promising therapeutic approach for the treatment of cancer. However, there is as yet no …
promising therapeutic approach for the treatment of cancer. However, there is as yet no …
Regulation of repair of alkylation damage in mammalian genomes
S Mitra, B Kaina - Progress in nucleic acid research and molecular …, 1993 - Elsevier
Publisher Summary This chapter discusses the current understanding of the molecular basis
of the regulation of alkylation damage repair in mammals. Such molecular studies were not …
of the regulation of alkylation damage repair in mammals. Such molecular studies were not …
Modifying effect in vivo of interferon α on induction and repair of lesions in DNA of lymphoid cells of gamma-irradiated mice
NP Sirota, VG Bezlepkin, EA Kuznetsova… - Radiation …, 1996 - meridian.allenpress.com
The induction of structural lesions and repair in DNA of lymphoid cells from the peripheral
blood, spleen and thymus of mice treated with natural mouse interferon α (IFN-α) 24 and 48 …
blood, spleen and thymus of mice treated with natural mouse interferon α (IFN-α) 24 and 48 …
Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell lines
T Hotta, Y Saito, T Mikami, K Kurisu, K Kiya… - Journal of neuro …, 1993 - Springer
In order to study the dynamic relationship in glioma cells between O 6-alkylguanine-DNA
alkyltransferase (AGT) activity and resistance to the cytotoxic effect of …
alkyltransferase (AGT) activity and resistance to the cytotoxic effect of …
The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents
J Miyakoshi, DA Scudiero, J Allalunis-Turner… - Mutation Research/DNA …, 1991 - Elsevier
Abstract 4 repair-deficient (Mer−) and 2 repair-proficient (Mer+) lines of SV40-transformed
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
human fibroblasts were assayed for colony-forming ability after treatment with MNNG, methyl …
Effect of human recombinant interferon-α on the activity of cis-diamminedichloroplatinum (II) in human non-small cell lung cancer xenografts
RC French, A Bowman, KG MacLeod… - Cancer …, 1995 - Taylor & Francis
Interferons (IFNs) augment the effect of some antitumor agents, including
cisdiamminedichloroplatinum (II)(cDDP), in experimental systems. The effect of human …
cisdiamminedichloroplatinum (II)(cDDP), in experimental systems. The effect of human …
O6-Alkylguanine DNA Alkyltransferase Is Induced by Human Recombinant Interferon-αA/D in Mouse Liver
P Coccia, R Bertini, P Pagani, C Marinello… - Journal of interferon …, 1992 - liebertpub.com
Treatment of C57Bl or BALB/C mice with human interferon-αA/D (HuIFN-αA/D) significantly
increased hepatic levels of the DNA repair enzyme O 6-alkylguanine DNA alkyltransferase …
increased hepatic levels of the DNA repair enzyme O 6-alkylguanine DNA alkyltransferase …
[图书][B] Retroviral-mediated transfer and expression of the human O (6)-methylguanine-DNA methyltransferase gene in murine hematopoietic stem cells
G Wang - 1996 - search.proquest.com
Abstract $ O\sp6 $-Methylguanine-DNA methyltransferase (MGMT) is an important DNA
repair protein that plays a key role in cancer chemotherapy by alkylating drugs. However …
repair protein that plays a key role in cancer chemotherapy by alkylating drugs. However …
[引用][C] What is synergy?
MC Berenbaum - Pharmacological reviews, 1989 - ASPET