Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …

The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ
transplantation. Both compounds are still widely used in the clinic as well as for basic …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of cognitive functions. While the exact causes of this debilitating disorder remain …

Diabetic nephropathy (DN) is a serious complication of both type 1 and type 2 diabetes
mellitus. The disease is now the most common cause of end-stage kidney disease (ESKD) …

As a profoundly anabolic regulator of bone, Wnt7b is well acknowledged to enhance
osteoblast activities. Here, we report that bone marrow mesenchymal stem cells (BMSCs) …

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in
disordered regions of other proteins drives cellular signaling. Mapping the energy …

Skin is the second most common organ (after the kidney) to be affected in patients with
systemic lupus erythematosus (SLE), yet the aetiology of skin injury and the mechanisms …

Tumor necrosis factor alpha (TNFα) inhibitors are a mainstay of treatment for rheumatoid
arthritis (RA) patients after failed responses to conventional disease-modifying antirheumatic …

Two genes on chromosome 21, namely dual specificity tyrosine phosphorylation-regulated
kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been implicated in some …

OX40L is one of the co-stimulatory molecules that can be expressed by splenic lymphoid
tissue inducer (Lti) cells, a subset of group 3 innate lymphoid cells (ILC3s). OX40L …