Cachexia is a multifactorial process of skeletal muscle and adipose tissue atrophy resulting
in progressive weight loss. It is associated with poor quality of life, poor physical function …

Decreased appetite and involuntary weight loss are common occurrences in chronic
disease and have a negative impact on both quality of life and eventual mortality. Weight …

Skeletal muscle catabolism is a co-morbidity of many chronic diseases and is the result of
systemic inflammation. Although direct inflammatory cytokine action on muscle promotes …

Cancer anorexia-cachexia syndrome (CACS) is the most frequent paraneoplastic syndrome
occurring in half of all oncologic patients and is considered as a poor prognosticator …

Major depression is one of the most prevalent mental disorders, causing significant human
suffering and socioeconomic loss. Since conventional antidepressants are not sufficiently …

[Frontiers in Bioscience S2, 1009-1046, June 1, 2010] 1009 Thermoregulation, energy balance,
regulatory peptides: recent develop Page 1 [Frontiers in Bioscience S2, 1009-1046, June 1 …

High-density lipoprotein (HDL) oxylipins regulate inflammation, and acute systemic
inflammation can precipitate cognitive impairment. Females have more HDL and stronger …

Over the past century, overwhelming evidence has emerged pointing to the hypothalamus of
the central nervous system (CNS) as a crucial regulator of systemic control of metabolism …

Cancer and its morbidities, such as cancer cachexia, constitute a major public health
problem. Although cancer cachexia has afflicted humanity for centuries, its underlying …

Cachexia is a devastating syndrome of body wasting that is associated with multiple
common chronic diseases including cancer, chronic kidney disease, and chronic heart …