The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

The extracellular matrix (ECM) plays an important role in cancer progression. It can be
divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior …

High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk,
critically affecting metastasis and treatment resistance, remains elusive. Our results show …

We have profiled, for the first time, an evolving human metastatic microenvironment by
measuring gene expression, matrisome proteomics, cytokine and chemokine levels …

High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular
subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most
common extracranial tumor of childhood. By sequencing transcriptomes of low-and high-risk …

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and
is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) …