Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent
accumulation of lipid hydroperoxides to lethal levels. Necroptosis, an alternative form of …

Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …

Iron is critical to the survival of almost all living organisms. However, inappropriately low or
high levels of iron are detrimental and contribute to a wide range of diseases. Recent …

Although iron is one of the most abundant elements on earth, about a third of the world's
population are affected by iron deficiency. Main drivers of iron deficiency are beside the …

Iron and ascorbate are vital cellular constituents in mammalian systems. The bulk-
requirement for iron is during erythropoiesis leading to the generation of hemoglobin …

This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron
homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2 …

The molecular mechanisms of iron trafficking in neurons have not been elucidated. In this
study, we characterized the expression and localization of ferrous iron transporters Zip8 …

Dcytb (duodenal cytochrome b) is an iron-regulated ferric reductase highly expressed in
duodenal enterocytes. Its location and strong regulation by iron has indicated it plays an …

Abstract Significance: Cytochromes b 561 (CYB561s) constitute a family of trans-membrane
(TM), di-heme proteins, occurring in a variety of organs and cell types, in plants and animals …

Ionic copper entering blood plasma binds tightly to albumin and the macroglobulin
transcuprein. It then goes primarily to the liver and kidney except in lactation, where a large …