GABAB receptors are broadly expressed in the nervous system and have been implicated in
a wide variety of neurological and psychiatric disorders. The cloning of the first GABAB …

Abstract γAminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. GABA is converted from glutamic acid by the action of glutamic acid …

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent
molecular pharmacology studies demonstrated that alcohol has only a few known primary …

Symptoms of alcohol withdrawal syndrome (AWS) may develop within 6–24 h after the
abrupt discontinuation or decrease of alcohol consumption. Symptoms can vary from …

The γ-aminobutyric acidB (GABAB) receptor was first demonstrated on presynaptic terminals
where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter …

Aims: The γ-aminobutyric acid (GABAB) receptor agonist, baclofen, has recently been
shown to reduce alcohol intake in alcohol-preferring rats and alcohol consumption and …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Alcoholism is a major public health problem and resembles, in many ways, other chronic
relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer …

The past decade has seen an expansion of research and knowledge on pharmacotherapy
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …

Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …