[HTML][HTML] Recent insights into the role of defensins in diabetic wound healing

G Li, Q Wang, J Feng, J Wang, Y Wang… - Biomedicine & …, 2022 - Elsevier
Diabetic wound, one of the most common serious complications of diabetic patients, is an
important factor in disability and death. Much of the research on the pathophysiology of …

Sepsis-associated encephalopathy: From pathophysiology to clinical management

Y Hong, P Chen, J Gao, Y Lin, L Chen… - International …, 2023 - Elsevier
Sepsis-associated encephalopathy, which presents as delirium and coma, is a significant
complication of sepsis characterized by acute brain dysfunction. The presence of …

Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated by perineuronal net might contribute to cognitive impairments in a mouse model of …

L Zhang, YZ Gao, CJ Zhao, JY Xia, JJ Yang, MH Ji - Neuropharmacology, 2023 - Elsevier
Sepsis-associated encephalopathy (SAE) is commonly defined as diffuse brain dysfunction
and can manifest as delirium to coma. Accumulating evidence has suggested that …

Repetitive intermittent hyperglycemia drives the M1 polarization and inflammatory responses in THP-1 macrophages through the mechanism involving the TLR4-IRF5 …

F Al-Rashed, S Sindhu, H Arefanian, A Al Madhoun… - Cells, 2020 - mdpi.com
Repetitive intermittent hyperglycemia (RIH) is an independent risk factor for complications
associated with type-2 diabetes (T2D). Glucose fluctuations commonly occur in T2D patients …

Association of Septic Shock with Mortality in Hospitalized COVID‐19 Patients in Wuhan, China

S Chen, Z Gao, L Hu, Y Zuo, Y Fu, M Wei… - Advances in …, 2022 - Wiley Online Library
Purpose. Septic shock is a severe complication of COVID‐19 patients. We aim to identify risk
factors associated with septic shock and mortality among COVID‐19 patients. Methods. A …

Crosstalk between septic shock and venous thromboembolism: a bioinformatics and immunoassay analysis

Z Li, C Wang, X Zhang, X Xu, M Wang… - Frontiers in cellular and …, 2023 - frontiersin.org
Background Herein, we applied bioinformatics methods to analyze the crosstalk between
septic shock (SS) and venous thromboembolism (VTE), focusing on the correlation with …

Comprehensive analysis of senescence-associated genes in sepsis based on bulk and single-cell sequencing data

L Tao, Y Zhu, L Wu, J Liu - Frontiers in Molecular Biosciences, 2024 - frontiersin.org
Background: Sepsis is a pathological state resulting from dysregulated immune response in
host during severe infection, leading to persistent organ dysfunction and ultimately death …

based biosensor for the detection of sepsis using MMP-9 biomarker in FIP mice model

NK Alekhmimi, Z Raddadi, AA Alabdulwahed, S Eissa… - Biosensors, 2023 - mdpi.com
Sepsis is an immune response to a microbial invasion that causes organ injury and
dysfunction due to a systemic inflammatory response. Sepsis is a serious, life-threatening …

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation

F Al-Rashed, H Arefanian, AA Madhoun, F Bahman… - Cells, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin
resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and …

Human beta defensins may be a multifactorial modulator in the management of diabetic wound

BKR Sanapalli, V Yele, RSR Kalidhindi… - Wound Repair and …, 2020 - Wiley Online Library
Diabetic wound (DW) is considered as one of the serious complications associated with
diabetes mellitus. Though some pharmacological approaches are available for managing …