Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Chronic pancreatitis is a clinical entity that results from the progressive inflammation and
irreversible fibrosis of the pancreas resulting from the cumulative injury sustained by the …

Background and aims The SPINK1 c. 194+ 2T> C variant has been increasingly recognized
as an important risk factor for chronic pancreatitis (CP). However, there is no clear …

The calcium-sensing receptor (CASR) is expressed in the pancreas where it might regulate
calcium concentrations in pancreatic secretions. Two independent studies reported …

Liquid chromatography with tandem mass spectrometry (LC-MS/MS) is a proteome analysis
method, and the shotgun analysis by LC-MS/MS comprehensively identifies proteins from …

Chronic pancreatitis is a progressive inflammatory disorder of the pancreas, which often
develops as a result of genetic predisposition. Some of the most frequently identified risk …

Human chymotrypsin-like elastases 3A and 3B (CELA3A and CELA3B) are the products of
gene duplication and share 92% identity in their primary structure. CELA3B forms stable …

ABSTRACT Background/Objectives Loss-of-function chymotrypsin C (CTRC) variants
increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC …

Recently, our resequencing of the promoter region of PRSS1 in French Caucasian
individuals led to the identification of a functional variant (c.‐204C> A) that is in perfect …