Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

GRIA1 encodes the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate
(AMPA) receptors, which are ligand-gated ion channels that act as excitatory receptors for …

INTRODUCTION Ionotropic glutamate receptors (iGluRs) are cation channels that mediate
signal transmission by depolarizing the postsynaptic membrane in response to L-glutamate …

AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and
are selectively recruited during activity-dependent plasticity to increase synaptic strength. A …

l-Glutamate is the main excitatory neurotransmitter in the brain, with postsynaptic responses
to its release predominantly mediated by AMPA-type glutamate receptors (AMPARs). A …

AMPA receptors (AMPARs) play a critical role in excitatory glutamatergic neurotransmission.
The number and subunit composition of AMPARs at synapses determines the dynamics of …

Ionotropic glutamate receptors (iGluRs) are ligand‐gated ion channels that open their ion‐
conducting pores in response to the binding of agonist glutamate. In recent years, significant …

Ligand-gated ion channels (LGICs) mediate fast synaptic transmission in the CNS. Typically,
these membrane proteins are multimeric complexes associating several homologous …

AMPA-type glutamate receptors (AMPARs) mediate fast neurotransmission at excitatory
synapses. The extent and fidelity of postsynaptic depolarization triggered by AMPAR …