What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Dynamics of translation of single mRNA molecules in vivo
X Yan, TA Hoek, RD Vale, ME Tanenbaum - Cell, 2016 - cell.com
Regulation of mRNA translation, the process by which ribosomes decode mRNAs into
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …
Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues
Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …
Evolution and biological roles of alternative 3′ UTRs
C Mayr - Trends in cell biology, 2016 - cell.com
More than half of human genes use alternative cleavage and polyadenylation to generate
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
alternative 3′ untranslated region (3′ UTR) isoforms. Most efforts have focused on …
Nudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling
Cell fate transitions involve rapid gene expression changes and global chromatin
remodeling, yet the underlying regulatory pathways remain incompletely understood. Here …
remodeling, yet the underlying regulatory pathways remain incompletely understood. Here …
A comprehensive analysis of 3′ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on …
Alternative polyadenylation (APA) is a general mechanism of transcript diversification in
mammals, which has been recently linked to proliferative states and cancer. Different 3 …
mammals, which has been recently linked to proliferative states and cancer. Different 3 …
Cleavage and polyadenylation: Ending the message expands gene regulation
J Neve, R Patel, Z Wang, A Louey, AM Furger - RNA biology, 2017 - Taylor & Francis
Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
of primary protein encoding transcripts into functional mRNAs that can be exported from the …
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously
expressed regulators of RNA processing. To understand the molecular impact of ALS …
expressed regulators of RNA processing. To understand the molecular impact of ALS …
Comparative Evaluation of the Nutritive, Mineral, and Antinutritive Composition of Musa sinensis L. (Banana) and Musa paradisiaca L. (Plantain) Fruit Compartments
BO Oyeyinka, AJ Afolayan - Plants, 2019 - mdpi.com
Banana and plantain contribute significantly to food security and amelioration of
malnutrition, earning their status as staples in several localities of tropical and sub-tropical …
malnutrition, earning their status as staples in several localities of tropical and sub-tropical …