Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this …

Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …

Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

Microbiota are thought to influence the development and progression of inflammatory bowel
disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires …

Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection by
shaping the resident microbiota community, restricting the growth of bacterial pathogens and …

Maternal immune activation (MIA) contributes to behavioural abnormalities associated with
neurodevelopmental disorders in both primate and rodent offspring,,,. In humans …

The study of the intestinal microbiota has begun to shift from cataloging individual members
of the commensal community to understanding their contributions to the physiology of the …