Since their discovery in the 1960s, the family of Fe (II)/2-oxoglutarate-dependent
oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast …

Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …

Abstract Novofumigatonin (1), isolated from the fungus Aspergillus novofumigatus, is a
heavily oxygenated meroterpenoid containing a unique orthoester moiety. Despite the wide …

Pyridoxal phosphate-dependent enzymes able to use oxygen as a co-substrate have
emerged in multiple protein families. Here, we use crystallography to solve the 2.40 Å …

Capuramycins are antimycobacterial antibiotics that consist of a modified nucleoside named
uridine-5′-carboxamide (CarU). Previous biochemical studies have revealed that CarU is …

Covering: up to September 2020 Hundreds of nucleoside-based natural products have been
isolated from various microorganisms, several of which have been utilized in agriculture as …

Muraymycins belong to a family of nucleoside antibiotics that have a distinctive disaccharide
core consisting of 5-amino-5-deoxyribofuranose (ADR) attached to 6′-N-alkyl-5′-C …

Nucleoside natural products show diverse biological activities and serve as leads for various
application purposes, including human and veterinary medicine and agriculture. Studies in …

Cell wall biosynthesis represents a valid target for antibacterial action but only a limited
number of chemical structure classes selectively interact with specific enzymes or protein …

Mycobacterium tuberculosis (Mtb) has recently surpassed HIV/AIDS as the leading cause of
death by a single infectious agent. The standard therapeutic regimen against tuberculosis …